Contrasting roles of H3K4me3 and H3K9me3 in regulation of apoptosis and gemcitabine resistance in human pancreatic cancer cells

Abstract Background Pancreas ductal adenocarcinoma (PDAC) has the most dismal prognosis among all human cancers since it is highly resistant to chemotherapy, radiotherapy and immunotherapy.The anticipated consequence of all therapies is induction of tumor apoptosis.The highly resistance nature of PDACs to all therapies suggests jumper cable that th

read more


La sifilide a Napoli nel tardo Quattrocento

This paper aims to trace, through historical and medical sources, the syphilis epidemic that broke out in Naples in Fineliner the late 15th century.When the disease overspread, the chronicles attributed the plague to the conquest of Naples by the king of France Charles VIII.Because of this, the disease was named morbus gallicus by the Italians and

read more